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Scientific Opinion on the efficacy of Biosprint® (Saccharomyces cerevisiae) as a feed additive for cattle for fattening

EFSA Journal 2013;11(4):3174 [6 pp.]. doi:10.2903/j.efsa.2013.3174
  EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel Members Gabriele Aquilina, Alex Bach, Vasileios Bampidis, Maria De Lourdes Bastos, Gerhard Flachowsky, Mikolaj Antoni Gralak, Christer Hogstrand, Lubomir Leng, Secundino López-Puente, Giovanna Martelli, Baltasar Mayo, Derek Renshaw, Guido Rychen, Maria Saarela, Kristen Sejrsen, Patrick Van Beelen, Robert John Wallace and Johannes Westendorf. Acknowledgment The Panel wishes to thank the members of the Working Group on Micro-Organisms including Andrew Chesson, Pier Sandro Cocconcelli and Ingrid Halle, for the preparatory work on this scientific opinion Contact FEEDAP@efsa.europa.eu
Type: Opinion of the Scientific Committee/Scientific Panel On request from: European Commission Question number: EFSA-Q-2012-00925 Adopted: 13 March 2013 Published: 08 April 2013 Affiliation: European Food Safety Authority (EFSA), Parma, Italy
Abstract

In a previous opinion on Biosprint, the FEEDAP Panel could not conclude on the efficacy of this additive when used in feed for cattle for fattening because of insufficient evidence. The European Commission has requested the European Food Safety Authority to re-evaluate the efficacy of the additive Biosprint® when used as a zootechnical additive (functional group: gut flora stabilisers) in diets for cattle for fattening at a minimum dose of 4.0 × 109 and a maximum dose of 9.0 × 109 CFU/kg complete feedingstuffs. In the present application, the results of two new efficacy studies performed in cattle for fattening were presented. Both showed significant improvements in final body weight, average daily gain and feed to gain ratio in Biosprint®-treated animals. Taking into account the positive result from the initial application, the FEEDAP Panel concludes that Biosprint® has the potential to be efficacious in cattle for fattening at the dose of 3.6 × 1010 CFU/head per day approximately equating to 4 × 109 CFU/kg feedingstuffs.

© European Food Safety Authority, 2013

Summary

In 2011 the European Food Safety Authority delivered an opinion on Biosprint® when used as a zootechnical additive (functional group: gut flora stabilisers) in diets for cattle for fattening at a minimum dose of 4.0 × 109 and a maximum dose of 9.0 × 109 CFU/kg complete feedingstuffs. The dossier submitted at that time included six efficacy studies, four of which could not be further considered owing to significant weaknesses in the experimental designs. Of the remaining two, only one showed evidence of a significant benefit in weight gain. As a consequence, the FEEDAP Panel was unable to conclude on the efficacy of Biosprint® when used in feed for cattle for fattening.
In the present application the results from two new efficacy studies performed with cattle for fattening were presented. Both showed significant improvements in final body weight, average daily gain and feed to gain ratio in Biosprint®-treated animals. Taking into account the positive result from the initial application, the FEEDAP Panel concludes that Biosprint® has the potential to be efficacious in cattle for fattening at the dose of 3.6 × 1010 CFU/head/day, equating to approximately 4 × 109 CFU/kg feedingstuffs.
 

Keywords

Zootechnical additive, gut flora stabiliser, Biosprint®, Saccharomyces cerevisiae, cattle for fattening, efficacy