Scientific Opinion on Flavouring Group Evaluation 222 (FGE.222): Consideration of genotoxicity data on representatives for alpha,beta-unsaturated furyl derivatives with the α,β-unsaturation in the side chain from subgroup 4.6 of FGE.19 by EFSA

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Article
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2012;10(5):2748 [18 pp.].
doi
10.2903/j.efsa.2012.2748
Panel members at the time of adoption
Ulla Beckman Sundh, Mona-Lise Binderup, Leon Brimer, Laurence Castle, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Catherine Leclercq, Jean Claude Lhuguenot, Wim Mennes, Maria Rosaria Milana, Iona Pratt, Kettil Svensson, Maria de Fatima Tavares Pocas, Fidel Toldra, Detlef Wölfle
Acknowledgements

The Panel wishes to thank the members of the CEF Working Group on Genotoxicity: Mona-Lise Binderup, Wilfried Bursch, Angelo Carere, Riccardo Crebelli, Rainer Guertler, Daniel Marzin, Pasquale Mosesso for the preparatory work on this scientific opinion the hearing experts: Vibe Beltoft, Pia Lund, Karin Nørby and EFSA staff: Andrea Terron and Kim Rygaard Nielsen for the support provided to this scientific opinion.

Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2012-00248
EFSA-Q-2012-00249
EFSA-Q-2012-00250
EFSA-Q-2012-00251
EFSA-Q-2012-00391
EFSA-Q-2012-00392
Adopted
24. Mai 2012
Published in the EFSA Journal
30. Mai 2012
Last Updated
7. Juni 2012. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of six flavouring substances from subgroup 4.6 of FGE.19 in the Flavouring Group Evaluation 222. The Flavour Industry have provided additional genotoxicity studies for two representative substances, 3-(2-furyl)acrylaldehyde [FL-no: 13.034] and 4-(2-furyl)but-3-en-2-one [FL-no: 13.044], in FGE.222. Based on these new data the Panel could not rule out a clastogenic and aneugenic potential for the two substances and a in vivo Comet assay was requested for both substances, the one including a micronucleus assay.

Keywords
FGE.222, α,β-unsaturated aldehydes and ketones
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Number of Pages
18