Scientific Opinion on Flavouring Group Evaluation 222 (FGE.222): Consideration of genotoxicity data on representatives for alpha,beta-unsaturated furyl derivatives with the α,β-unsaturation in the side chain from subgroup 4.6 of FGE.19 by EFSA

FGE.222, α,β-unsaturated aldehydes and ketones
First published in the EFSA Journal
30. Mai 2012
24. Mai 2012
Last Updated
7. Juni 2012. This version replaces the previous one/s.
Scientific Opinion


The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of six flavouring substances from subgroup 4.6 of FGE.19 in the Flavouring Group Evaluation 222. The Flavour Industry have provided additional genotoxicity studies for two representative substances, 3-(2-furyl)acrylaldehyde [FL-no: 13.034] and 4-(2-furyl)but-3-en-2-one [FL-no: 13.044], in FGE.222. Based on these new data the Panel could not rule out a clastogenic and aneugenic potential for the two substances and a in vivo Comet assay was requested for both substances, the one including a micronucleus assay.

Panel members at the time of adoption

Ulla Beckman Sundh, Mona-Lise Binderup, Leon Brimer, Laurence Castle, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Catherine Leclercq, Jean Claude Lhuguenot, Wim Mennes, Maria Rosaria Milana, Iona Pratt, Kettil Svensson, Maria de Fatima Tavares Pocas, Fidel Toldra, Detlef Wölfle
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
cef [at]
EFSA Journal 2012;10(5):2748
On request from
European Commission